Authors
Sebastian Mohnke, Susanne Erk, Knut Schnell, Claudia Schütz, Nina Romanczuk-Seiferth, Oliver Grimm, Leila Haddad, Lydia Pöhland, Maria Garbusow, Mike M Schmitgen, Peter Kirsch, Christine Esslinger, Marcella Rietschel, Stephanie H Witt, Markus M Nöthen, Sven Cichon, Manuel Mattheisen, Thomas Mühleisen, Jimmy Jensen, Björn H Schott, Wolfgang Maier, Andreas Heinz, Andreas Meyer-Lindenberg, Henrik Walter
Publication date
2014/4
Journal
Neuropsychopharmacology
Volume
39
Issue
5
Pages
1196-1205
Publisher
Nature Publishing Group
Description
The single-nucleotide polymorphism (SNP) rs1344706 in ZNF804A is one of the best-supported risk variants for psychosis. We hypothesized that this SNP contributes to the development of schizophrenia by affecting the ability to understand other people’s mental states. This skill, commonly referred to as Theory of Mind (ToM), has consistently been found to be impaired in schizophrenia. Using functional magnetic resonance imaging, we previously showed that in healthy individuals rs1344706 impacted on activity and connectivity of key areas of the ToM network, including the dorsomedial prefrontal cortex, temporo-parietal junction, and the posterior cingulate cortex, which show aberrant activity in schizophrenia patients, too. We aimed to replicate these results in an independent sample of 188 healthy German volunteers. In order to assess the reliability of brain activity elicited by the ToM task, 25 participants …
Total citations
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